After extensive treatments for his vocal problems—and a two-year hiatus—Mayer began performing as a singer again in January 2013, and that year released the album, Paradise Valley.The album is named for where he lives in Montana and features country music influences.Reflecting on the incident, Mayer said, "That was the moment the songwriter in me was born", and he penned his first lyrics the night he left the hospital.
This intermediate undergoes the key step of the synthesis, a oxidative ring opening of the quinoline with sodium periodate and ruthenium oxide, leading to the triazolobenzophenone.
The 1,3,4-triazole is treated with formaldehyde to provide hydroxymethyl intermediate, subsequent bromination using phosphorous tribromide gives bromomethyltriazole which after spontaneous cyclization with ammonia produces the Alprazolam.
Though Mayer started his career mainly performing acoustic rock, he began moving towards the blues genre that had originally influenced him as a musician. Forming the John Mayer Trio, he released a live album in 2005 called Try! Both albums received wide critical acclaim, and Continuum earned Mayer a 2007 Grammy Award for Best Pop Vocal Album.
By 2005, he was collaborating with blues artists such as B. He also won Best Male Pop Vocal Performance for "Waiting on the World to Change".
By 2014, he had sold a total of over 20 million albums worldwide.